Concept About Pethidine | CHAPTER-7 | Pharmacology

Concept About Pethidine – This book covers the entire syllabus of “Pharmacology” prescribed by BNMC- for a diploma in nursing science & midwifery students. We tried to accommodate the latest information and topics. This book is an examination set up according to the teachers’ lectures and examination questions.

At the end of the book, previous questions are given. We hope in touch with the book students’ knowledge will be upgraded and flourish. The unique way of presentation may make your reading of the book a pleasurable experience.

Concept About Pethidine

1. Pethidine is also known as meperidine.

2. It is a synthetic substitute for morphine.

3. Less potent analgesic than morphine.

4. Absorbed from Gastrointestinal tract (GIT).

5. Plasma protein binding capacity: Partially.

6. Bioavailability: 40-60% with oral route but more in parenteral route.

7. Short duration of action (2-3 hours); hence pethidine is preferred to morphine for analgesia during labor.

8. Metabolized in liver by hydrolysis to pethidine acid or demethylation to norpethedine & hydrolysis to norpetherdinie acid, followed by conjugation with glucoronic acid.

9. Large dose shows:

10. Anti-cholinergic action:

• Mydriasis
• Antispasmodic action
• Atropine like side effects
• Anti-histaminic action.

11. Uses:

Used as analgesic in –

1. Severe pain

2. Renal colic

3. Minor surgery

4. Ophthalmology, dentistry

5. Also used in-

6. Preoperative medication and

7. As an adjunct to anaesthesia

8. To relieve pain of labour

9. Spasm of GIT, uterus & urinary bladder.

Pethidine does not suppress cough usefully

Adverse effects of pethidine

• Dryness of mouth
• Blurring of vision
• Transient hypotension &
• Hallucination

Difference between Morphine and Pethidine

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• Non Opieds | CHAPTER-7 | Pharmacology